Agmatine Sulfate: Enhance Focus, Boost Dopamine &…

Boost Dopamine, Energy, Workouts & Reduce Pain!

Agmatine sulfate is a compound derived from the amino acid arginine, and it’s become popular in the supplement world—especially for cognitive support, mood, and pain management, as well as athletic performance.

> Here’s a quick rundown of what it does or is thought to do:

• Neurotransmitter Modulation
• Pain Management
• Exercise Enhancer: Nitric Oxide Booster / Pre-Workout
• Kratom booster, potentiator; Kratom cessation aid.

Neurotransmitter Modulation

• Acts on receptors for serotonin, dopamine, and norepinephrine—this gives it potential antidepressant and anxiolytic (anti-anxiety) effects.

• May support neuroprotection and memory by regulating NMDA receptors and nitric oxide levels.

Pain Management

• Agmatine appears to modulate pain perception by influencing opioid and NMDA receptors—some even use it as an adjunct to pain medications.

Nitric Oxide Booster / Pre-Workout

• It can help regulate nitric oxide synthesis, which may support vasodilation (wider blood vessels), making it a common pre-workout ingredient for better pumps and blood flow.

Kratom Enhacing & Tolerance Maintenance:

If you’re pairing it with kratom (to lower dosage, tolerance or experimentation), some prefer to take agmatine sulfate either:

• circa 25 – 50 mg taken 30 – 45 min after kratom dosage.

• circa 25 – 50 mg taken with the kratom dosage (start low & find your sweet spot)

• circa 25 – 50 mg taken 30 to 60 minutes beforehand

*It may interact with medications, especially psychiatric or blood pressure drugs. Not a lot of long-term human studies yet—most evidence is from animal research or anecdotal.